Pneumomediastinum following Enteryx injection for the treatment of gastroesophageal reflux disease.

We describe the case of a 68-year-old female who developed pneumomediastinum following the "Enteryx" procedure for the treatment of gastroesophageal reflux disease (GERD). The patient required hospitalization and parenteral antibiotics and responded favorably to a conservative approach. Similar complications have been observed with other endoscopic treatment modalities for GERD such as Stretta and suturing techniques. Our patient represents the third reported case of a serious complication after Enteryx implantation.