| Literature DB >> 15743173 |
Steven Harper1, Barbara Pacini, Salvatore Avolio, Marcello Di Filippo, Giovanni Migliaccio, Ralph Laufer, Raffaele De Francesco, Michael Rowley, Frank Narjes.
Abstract
Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.Entities:
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Year: 2005 PMID： 15743173 DOI： 10.1021/jm049122i
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446