Verbal fluency component analysis in adults with HIV/AIDS.

The present study examined the impact of HIV disease severity, depressed mood, and highly-active antiretroviral therapy (HAART) on verbal fluency components in a sample of adults with HIV-infection. Switching and clustering have been identified as dissociable components that contribute to performance on tests of phonemic and semantic verbal fluency. Advanced HIV-infection was predicted to differentially impair switching. Switching has been shown to be reduced in disorders affecting frontal-striatal systems (e.g., Parkinson's disease). Verbal fluency protocols (FAS and Animals) of 217 adults with HIV-infection were scored for total switches and average cluster size following the method of Troyer, et al. (1998). Component scores were compared to published norms. Analysis of variance (ANOVA) was used to examine the impact on switching and clustering performance of (1) HIV disease severity (presence of AIDS diagnosis) and depressed mood, and (2) AIDS diagnosis and medication status (current HAART therapy). FAS switching was more often impaired in participants with AIDS. Depressed mood did not affect switching. Neither AIDS diagnosis nor depressed mood was associated with clustering performance. Participants with an AIDS diagnosis who were receiving HAART showed better performance on FAS switching relative to participants with AIDS who were not taking antiretroviral medication. FAS switching appears to be sensitive to cognitive changes associated with advanced HIV-infection. Further research is needed to determine if switching is a specific marker of frontal-striatal dysfunction in this population.