BACKGROUND: Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. METHOD: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. RESULTS: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. CONCLUSIONS: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
BACKGROUND:Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. METHOD: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. RESULTS: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. CONCLUSIONS: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
Authors: Curtis K Deutsch; Deborah L Levy; Selya F R Price; J Alexander Bodkin; Lenore Boling; Michael J Coleman; Fred Johnson; Jan Lerbinger; Steven Matthysse; Philip S Holzman Journal: Schizophr Bull Date: 2015-03-20 Impact factor: 9.306
Authors: Hanne Hoskens; Dongjing Liu; Sahin Naqvi; Myoung Keun Lee; Ryan J Eller; Karlijne Indencleef; Julie D White; Jiarui Li; Maarten H D Larmuseau; Greet Hens; Joanna Wysocka; Susan Walsh; Stephen Richmond; Mark D Shriver; John R Shaffer; Hilde Peeters; Seth M Weinberg; Peter Claes Journal: PLoS Genet Date: 2021-05-13 Impact factor: 5.917
Authors: Quentin Ferry; Julia Steinberg; Caleb Webber; David R FitzPatrick; Chris P Ponting; Andrew Zisserman; Christoffer Nellåker Journal: Elife Date: 2014-06-24 Impact factor: 8.140