| Literature DB >> 1574116 |
N A Thornberry1, H G Bull, J R Calaycay, K T Chapman, A D Howard, M J Kostura, D K Miller, S M Molineaux, J R Weidner, J Aunins.
Abstract
Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and the design of potent peptide aldehyde inhibitors are described. Purification and cloning of the complementary DNA indicates that IL-1 beta-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target.Entities:
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Year: 1992 PMID： 1574116 DOI： 10.1038/356768a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962