| Literature DB >> 15740892 |
Geneviève Philippe1, Luc Angenot, Patrick De Mol, Eric Goffin, Marie-Pierre Hayette, Monique Tits, Michel Frédérich.
Abstract
The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.Entities:
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Year: 2005 PMID： 15740892 DOI： 10.1016/j.jep.2004.12.011
Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360