Literature DB >> 15740888

Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux.

Keyong-Ho Lee1, Hye-Ran Choi, Chang-Han Kim.   

Abstract

Benincasa hispida in Korea was used mainly diabetes and diuresis diseases. This study was carried out to evaluate anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor found in various tumors. In this study, we found that the seed extract of Benincasa hispida Cogniaux decreased bFGF-induced endothelial cell proliferation and tube formation in a dose-dependent manner. Besides, Benincasa hispida seed extract showed no cytotoxicity on HUVECs and normal fibroblast cells. Furthermore, the seed extract of Benincasa hispida showed a potent inhibitory effect on bFGF-induced angiogenesis in vivo. These results suggest that the seed extract of Benincasa hispida inhibits the proliferation of endothelial cells induced by bFGF, which may explain its anti-angiogenic properties.

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Year:  2005        PMID： 15740888     DOI： 10.1016/j.jep.2004.12.008

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  8 in total

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2.  Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh.

Authors:  M Obayed Ullah; Mahmuda Haque; Kaniz Fatima Urmi; Abu Hasanat Md Zulfiker; Elichea Synthi Anita; Momtaj Begum; Kaiser Hamid
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3.  Fruit Derived Potentially Bioactive Bioengineered Silver Nanoparticles.

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Journal:  Int J Nanomedicine       Date:  2021-11-18

4.  Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer.

Authors:  Neng Wang; Zhi-Yu Wang; Sui-Lin Mo; Tjing Yung Loo; Dong-Mei Wang; Hai-Bin Luo; De-Po Yang; Yu-Ling Chen; Jian-Gang Shen; Jian-Ping Chen
Journal:  Breast Cancer Res Treat       Date:  2012-02-21       Impact factor: 4.872

5.  A review on angiogenesis and its assays.

Authors:  Zoya Tahergorabi; Majid Khazaei
Journal:  Iran J Basic Med Sci       Date:  2012-11       Impact factor: 2.699

6.  Comparative Study of the Chemical Compositions and Antioxidant Activities of Fresh Juices from Romanian Cucurbitaceae Varieties.

Authors:  Anna Cazanevscaia Busuioc; Andreea-Veronica Dediu Botezatu; Bianca Furdui; Costel Vinatoru; Filippo Maggi; Giovanni Caprioli; Rodica-Mihaela Dinica
Journal:  Molecules       Date:  2020-11-23       Impact factor: 4.411

Review 7.  A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles.

Authors:  Muhammad Torequl Islam; Cristina Quispe; Dina M El-Kersh; Manik Chandra Shill; Kanchan Bhardwaj; Prerna Bhardwaj; Javad Sharifi-Rad; Miquel Martorell; Rajib Hossain; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Monica Butnariu; Lia Sanda Rotariu; Hafiz Ansar Rasul Suleria; Yasaman Taheri; Anca Oana Docea; Daniela Calina; William C Cho
Journal:  Oxid Med Cell Longev       Date:  2021-12-10       Impact factor: 6.543

8.  Comparative Chloroplast Genome Analysis of Wax Gourd (Benincasa hispida) with Three Benincaseae Species, Revealing Evolutionary Dynamic Patterns and Phylogenetic Implications.

Authors:  Weicai Song; Zimeng Chen; Li He; Qi Feng; Hongrui Zhang; Guilin Du; Chao Shi; Shuo Wang
Journal:  Genes (Basel)       Date:  2022-03-04       Impact factor: 4.096
  8 in total

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