| Literature DB >> 15740841 |
Hon Chung Fung1, Jessica Evans, Whitney Evans, Jaime Duckworth, Alan Pittman, Rohan de Silva, Amanda Myers, John Hardy.
Abstract
We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of approximately 2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.Entities:
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Year: 2004 PMID： 15740841 DOI： 10.1016/j.neulet.2004.11.072
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046