K Schruers1, K Koning, J Luermans, M J Haack, E Griez. 1. Academic Anxiety Center, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands. koen.schruers@pn.unimaas.nl
Abstract
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a chronic disabling disease with profound implications for social functioning. Thirty per cent of all patients with OCD show insufficient improvement with state-of-the-art treatment. Conventional treatment and alternative treatment options for this population were investigated. METHOD: A selective review of the relevant scientific literature on OCD treatment and treatment resistance was conducted. RESULTS: In addition to serotonin reuptake inhibitors (SRIs) and cognitive-behavioural therapy, alternative monotherapies, SRI augmentation strategies with a variety of drugs and electroconvulsive therapy have shown results in individual cases, but no conclusive evidence has been found in placebo-controlled trials. While studies investigating neurosurgery for refractory OCD show positive results, most of these studies have methodological shortcomings. CONCLUSION: Novel approaches currently under investigation that have shown promising effects for treatment-resistant OCD include SRI augmentation with atypical antipsychotics and chronic deep brain stimulation, a new surgical technique. Placebo-controlled trials for both treatment options will be needed to confirm preliminary findings. Copyright 2005 Blackwell Munksgaard.
OBJECTIVE:Obsessive-compulsive disorder (OCD) is a chronic disabling disease with profound implications for social functioning. Thirty per cent of all patients with OCD show insufficient improvement with state-of-the-art treatment. Conventional treatment and alternative treatment options for this population were investigated. METHOD: A selective review of the relevant scientific literature on OCD treatment and treatment resistance was conducted. RESULTS: In addition to serotonin reuptake inhibitors (SRIs) and cognitive-behavioural therapy, alternative monotherapies, SRI augmentation strategies with a variety of drugs and electroconvulsive therapy have shown results in individual cases, but no conclusive evidence has been found in placebo-controlled trials. While studies investigating neurosurgery for refractory OCD show positive results, most of these studies have methodological shortcomings. CONCLUSION: Novel approaches currently under investigation that have shown promising effects for treatment-resistant OCD include SRI augmentation with atypical antipsychotics and chronic deep brain stimulation, a new surgical technique. Placebo-controlled trials for both treatment options will be needed to confirm preliminary findings. Copyright 2005 Blackwell Munksgaard.
Authors: Julia D Buckner; Kiara R Cromer; Katherine A Merrill; Michael A Mallott; Norman B Schmidt; Cristina Lopez; Jill M Holm-Denoma; Thomas E Joiner Journal: Cognit Ther Res Date: 2009
Authors: I Heitland; F Klumpers; R S Oosting; D J J Evers; J Leon Kenemans; J M P Baas Journal: Transl Psychiatry Date: 2012-09-25 Impact factor: 6.222