OBJECT: A grading system, called the Clinical-Radiological Grading System (CRGS), has been developed to standardize surgical indications in elderly patients harboring intracranial meningiomas. Patients with a score lower than 10 had a bad prognosis regardless of surgical treatment, those with a score between 10 and 12 had a prognosis positively influenced by surgery, and those with a score higher than 12 had a good prognosis regardless of surgical treatment. The authors performed a prospective cross-sectional study to validate further the use of the CRGS as a clinical tool to orientate surgical decision making in elderly patients and to explore prognostic factors of survival. METHODS: From 1990 to 2000 the authors consecutively recruited and surgically treated 90 patients 70 years of age or older with neuroimaging findings of intracranial meningiomas and a preoperative evaluation based on the CRGS. The surgical mortality rate, which covers deaths within 3 months after surgical intervention, was 7.8%, and the 1-year mortality rate was 15.6%. Female sex and a higher CRGS score were associated with a higher probability of survival. Among the different subset items of the CRGS score, no peritumoral edema for surgical survival and no concomitant diseases for 1-year survival provide the strongest predictive contribution, even if not at a statistically significant level. CONCLUSIONS: The CRGS score is a useful and practical tool for the selection of elderly patients affected by intracranial meningiomas as surgical candidates. A CRGS score higher than 10 and female sex are good prognostic factors of survival. whereas age is not a contraindication to surgery.
OBJECT: A grading system, called the Clinical-Radiological Grading System (CRGS), has been developed to standardize surgical indications in elderly patients harboring intracranial meningiomas. Patients with a score lower than 10 had a bad prognosis regardless of surgical treatment, those with a score between 10 and 12 had a prognosis positively influenced by surgery, and those with a score higher than 12 had a good prognosis regardless of surgical treatment. The authors performed a prospective cross-sectional study to validate further the use of the CRGS as a clinical tool to orientate surgical decision making in elderly patients and to explore prognostic factors of survival. METHODS: From 1990 to 2000 the authors consecutively recruited and surgically treated 90 patients 70 years of age or older with neuroimaging findings of intracranial meningiomas and a preoperative evaluation based on the CRGS. The surgical mortality rate, which covers deaths within 3 months after surgical intervention, was 7.8%, and the 1-year mortality rate was 15.6%. Female sex and a higher CRGS score were associated with a higher probability of survival. Among the different subset items of the CRGS score, no peritumoral edema for surgical survival and no concomitant diseases for 1-year survival provide the strongest predictive contribution, even if not at a statistically significant level. CONCLUSIONS: The CRGS score is a useful and practical tool for the selection of elderly patients affected by intracranial meningiomas as surgical candidates. A CRGS score higher than 10 and female sex are good prognostic factors of survival. whereas age is not a contraindication to surgery.
Authors: Giorgio Carrabba; Marco Riva; Valeria Conte; Andrea Di Cristofori; Manuela Caroli; Marco Locatelli; Massimo Castellani; Paolo Bucciarelli; Andrea Artoni; Nino Stocchetti; Ida Martinelli; Paolo Rampini Journal: J Neurooncol Date: 2018-03-02 Impact factor: 4.130
Authors: Andrea Di Cristofori; Barbara Zarino; Giulio Bertani; Marco Locatelli; Paolo Rampini; Giorgio Carrabba; Manuela Caroli Journal: J Neurooncol Date: 2018-01-12 Impact factor: 4.130
Authors: Daniel Monden; Florian J Raimann; Vanessa Neef; Daniel Dubinski; Florian Gessler; Fee Keil; Marie-Thérèse Forster; Michael W Ronellenfitsch; Patrick N Harter; Thomas M Freiman; Elke Hattingen; Volker Seifert; Christian Senft; Peter Baumgarten Journal: J Clin Med Date: 2021-04-22 Impact factor: 4.241
Authors: Christian Valentin Eisenring; Marian Christoph Neidert; Daniel Sabanés Bové; Leonhard Held; Johannes Sarnthein; Niklaus Krayenbühl Journal: PLoS One Date: 2013-11-14 Impact factor: 3.240