Literature DB >> 15738434

Sham surgery controls are mitigated trolleys.

R L Albin1.   

Abstract

Debate continues about the ethics of sham surgery controls. The most powerful argument for sham surgery controls is that rigorous experiments are needed to demonstrate safety and efficacy of surgical procedures. Without such experiments, there is danger of adopting worthless procedures in clinical practice. Opponents of sham surgery controls argue that sham surgery constitutes unacceptable violation of the rights of research subjects. Recent philosophical discussion has used two thought experiments-the transplant case and the trolley problem-to explore the circumstances under which individuals may be harmed to benefit a larger group. The transplant case is felt to exemplify circumstances that forbid harming some to benefit a larger group while the trolley problem exemplifies circumstances that permit harming some to benefit others. I argue that sham surgery controls satisfy criteria derived from the trolley problem and are morally permissible.

Keywords:  Analytical Approach; Biomedical and Behavioral Research; Philosophical Approach

Mesh:

Year:  2005        PMID: 15738434      PMCID: PMC1734102          DOI: 10.1136/jme.2003.006155

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  18 in total

1.  The ethical problems with sham surgery in clinical research.

Authors:  R Macklin
Journal:  N Engl J Med       Date:  1999-09-23       Impact factor: 91.245

2.  Use of placebo surgery in controlled trials of a cellular-based therapy for Parkinson's disease.

Authors:  T B Freeman; D E Vawter; P E Leaverton; J H Godbold; R A Hauser; C G Goetz; C W Olanow
Journal:  N Engl J Med       Date:  1999-09-23       Impact factor: 91.245

Review 3.  Do medical devices have enhanced placebo effects?

Authors:  T J Kaptchuk; P Goldman; D A Stone; W B Stason
Journal:  J Clin Epidemiol       Date:  2000-08       Impact factor: 6.437

Review 4.  Ethical framework for the use of sham procedures in clinical trials.

Authors:  Sam Horng; Franklin G Miller
Journal:  Crit Care Med       Date:  2003-03       Impact factor: 7.598

5.  Is placebo surgery unethical?

Authors:  Sam Horng; Franklin G Miller
Journal:  N Engl J Med       Date:  2002-07-11       Impact factor: 91.245

6.  Placebos that harm: sham surgery controls in clinical trials.

Authors:  Alex John London; Joseph B Kadane
Journal:  Stat Methods Med Res       Date:  2002-10       Impact factor: 3.021

7.  Surgery as placebo. A quantitative study of bias.

Authors:  H K BEECHER
Journal:  JAMA       Date:  1961-07-01       Impact factor: 56.272

8.  An evaluation of internal-mammary-artery ligation by a double-blind technic.

Authors:  L A COBB; G I THOMAS; D H DILLARD; K A MERENDINO; R A BRUCE
Journal:  N Engl J Med       Date:  1959-05-28       Impact factor: 91.245

9.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease.

Authors:  C R Freed; P E Greene; R E Breeze; W Y Tsai; W DuMouchel; R Kao; S Dillon; H Winfield; S Culver; J Q Trojanowski; D Eidelberg; S Fahn
Journal:  N Engl J Med       Date:  2001-03-08       Impact factor: 91.245

10.  A controlled trial of arthroscopic surgery for osteoarthritis of the knee.

Authors:  J Bruce Moseley; Kimberly O'Malley; Nancy J Petersen; Terri J Menke; Baruch A Brody; David H Kuykendall; John C Hollingsworth; Carol M Ashton; Nelda P Wray
Journal:  N Engl J Med       Date:  2002-07-11       Impact factor: 91.245

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  4 in total

Review 1.  Randomized sham-controlled trials in endoscopy: a systematic review and meta-analysis of adverse events.

Authors:  Allison R Schulman; Violeta Popov; Christopher C Thompson
Journal:  Gastrointest Endosc       Date:  2017-08-09       Impact factor: 9.427

Review 2.  Placebo in Surgical Research: A Case-Based Ethical Analysis and Practical Consequences.

Authors:  Sorin Hostiuc; Irina Rentea; Eduard Drima; Ionut Negoi
Journal:  Biomed Res Int       Date:  2016-08-10       Impact factor: 3.411

3.  Evidence-Based Evaluation of the Ethics of Sham Surgery for Parkinson's Disease.

Authors:  Stephen Polgar; Sheeza Mohamed
Journal:  J Parkinsons Dis       Date:  2019       Impact factor: 5.568

4.  Ethical considerations in the design, execution, and analysis of clinical trials of chronic pain treatments.

Authors:  Michael C Rowbotham; Michael P McDermott
Journal:  Pain Rep       Date:  2018-03-29
  4 in total

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