Neural substrates of childhood attention-deficit/hyperactivity disorder: electroencephalographic and magnetic resonance imaging evidence.

Research methods based on electroencephalogram (EEG) and anatomical and functional MRI have been used with increasing frequency in the study of childhood Attention-Deficit/Hyperactivity Disorder (ADHD). Both methods are safe and noninvasive, and their results can complement each other because of the good temporal (but relatively poorer spatial) resolution of EEG and the good spatial (but relatively poorer temporal) resolution of MRI. These methods are described, and associated recent research on childhood ADHD is summarized and critically examined. Results of this research support theories of ADHD that focus on a frontal-striatal neurological circuitry substrate, which has been implicated in neuropsychological executive functioning. A number of issues, however, such as the specificity of this finding for ADHD, remain unresolved. We conclude with an overview of advances and issues to be considered in future research on the neural substrates of childhood ADHD and advocate a developmental-contextual perspective on this disorder that acknowledges the reciprocal relations between neural structures and functions.