BACKGROUND: Her-2/neu protein is a member of the epidermal growth factor family of receptors which, upon activation, contributes positively to the growth and dissemination of neoplasia. Over-expression of this protein has been reported in different human tumors and shown to be a valuable prognostic factor especially in breast cancer. A limited number of studies have also shown positive correlation between Her-2/neu over-expression and advanced tumor progression in colorectal cancer. Here we studied the prevalence of Her-2/neu over-expression in Iranian colorectal cancer patients and assessed its correlation with the disease's progression. MATERIAL/ METHODS: Fifty-five colorectal cancer patients in different stages of disease were studied. The pathology specimens were immunohistochemically stained using monoclonal antibody against Her-2/neu protein. Correlation of the degree of staining with clinicopathological parameters was investigated. RESULTS: It was shown that in an Iranian population of colorectal cancer patients, the Her-2/neu oncogene is over-expressed in a significant number of cases and positively correlates with tumor stage and grade, being more frequent in the advanced and less differentiated samples. CONCLUSIONS: These data can be applied in designating new chemotherapeutic regimens using drugs that block the function of Her-2/neu in colorectal cancer patients in Iran.
BACKGROUND:Her-2/neu protein is a member of the epidermal growth factor family of receptors which, upon activation, contributes positively to the growth and dissemination of neoplasia. Over-expression of this protein has been reported in different humantumors and shown to be a valuable prognostic factor especially in breast cancer. A limited number of studies have also shown positive correlation between Her-2/neu over-expression and advanced tumor progression in colorectal cancer. Here we studied the prevalence of Her-2/neu over-expression in Iranian colorectal cancerpatients and assessed its correlation with the disease's progression. MATERIAL/ METHODS: Fifty-five colorectal cancerpatients in different stages of disease were studied. The pathology specimens were immunohistochemically stained using monoclonal antibody against Her-2/neu protein. Correlation of the degree of staining with clinicopathological parameters was investigated. RESULTS: It was shown that in an Iranian population of colorectal cancerpatients, the Her-2/neu oncogene is over-expressed in a significant number of cases and positively correlates with tumor stage and grade, being more frequent in the advanced and less differentiated samples. CONCLUSIONS: These data can be applied in designating new chemotherapeutic regimens using drugs that block the function of Her-2/neu in colorectal cancerpatients in Iran.
Authors: Asma Shabbir; Talat Mirza; Abdullah Bin Khalid; Muhammad Asif Qureshi; Sadaf Ahmed Asim Journal: BMC Cancer Date: 2016-11-07 Impact factor: 4.430