| Literature DB >> 15734681 |
Robert S Balaban1, Shino Nemoto, Toren Finkel.
Abstract
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.Entities:
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Year: 2005 PMID： 15734681 DOI： 10.1016/j.cell.2005.02.001
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582