Literature DB >> 15734104

Isolation of Delta9-THCA-A from hemp and analytical aspects concerning the determination of Delta9-THC in cannabis products.

Franz E Dussy1, Cornelia Hamberg, Marco Luginbühl, Thomas Schwerzmann, Thomas A Briellmann.   

Abstract

A simple procedure based on a common silica gel column chromatography for the isolation of Delta9-tetrahydrocannabinolic acid A (Delta9-THCA-A) from hemp in a multi-milligram scale is presented. Further, the decarboxylation reaction of Delta9-THCA-A to the toxicologically active Delta9-tetrahydrocannabinol (Delta9-THC) at different analytical and under-smoking conditions is investigated. Maximal conversion in an optimised analytical equipment yields about 70% Delta9-THC. In the simulation of the smoking process, only about 30 % of the spiked substance could be recovered as Delta9-THC.

Entities:  

Year:  2005        PMID： 15734104     DOI： 10.1016/j.forsciint.2004.05.015

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN： 0379-0738            Impact factor:   2.395


  32 in total

1.  Pharmacokinetics and tolerability of oral cannabis preparations in patients with medication overuse headache (MOH)-a pilot study.

Authors:  Lanfranco Pellesi; Manuela Licata; Patrizia Verri; Daniele Vandelli; Federica Palazzoli; Filippo Marchesi; Maria Michela Cainazzo; Luigi Alberto Pini; Simona Guerzoni
Journal:  Eur J Clin Pharmacol       Date:  2018-07-06       Impact factor: 2.953

Review 2.  Acidic Cannabinoid Decarboxylation.

Authors:  Crist N Filer
Journal:  Cannabis Cannabinoid Res       Date:  2021-09-22

Review 3.  Differentiating Cannabis Products: Drugs, Food, and Supplements.

Authors:  Arash Salehi; Keely Puchalski; Yalda Shokoohinia; Behzad Zolfaghari; Sedigheh Asgary
Journal:  Front Pharmacol       Date:  2022-06-27       Impact factor: 5.988

4.  Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography/Photodiode Array-Mass Spectrometry.

Authors:  Mei Wang; Yan-Hong Wang; Bharathi Avula; Mohamed M Radwan; Amira S Wanas; John van Antwerp; Jon F Parcher; Mahmoud A ElSohly; Ikhlas A Khan
Journal:  Cannabis Cannabinoid Res       Date:  2016-12-01

5.  Thermal stability of cannabinoids in dried cannabis: a kinetic study.

Authors:  Juris Meija; Garnet McRae; Christopher O Miles; Jeremy E Melanson
Journal:  Anal Bioanal Chem       Date:  2021-01-08       Impact factor: 4.142

6.  Delta9-THC determination by the EU official method: evaluation of measurement uncertainty and compliance assessment of hemp samples.

Authors:  Salvatore Sgrò; Benedicta Lavezzi; Cristian Caprari; Marco Polito; Marcello D'Elia; Giampietro Lago; Giada Furlan; Stefano Girotti; Elida Nora Ferri
Journal:  Anal Bioanal Chem       Date:  2021-03-23       Impact factor: 4.142

Review 7.  Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug.

Authors:  Shiri Procaccia; Gil Moshe Lewitus; Carni Lipson Feder; Anna Shapira; Paula Berman; David Meiri
Journal:  Front Pharmacol       Date:  2022-04-25       Impact factor: 5.988

8.  Kinetics of CBD, Δ9-THC Degradation and Cannabinol Formation in Cannabis Resin at Various Temperature and pH Conditions.

Authors:  Wuttichai Jaidee; Ittipon Siridechakorn; Siwames Nessopa; Vanuchawan Wisuitiprot; Nathareen Chaiwangrach; Kornkanok Ingkaninan; Neti Waranuch
Journal:  Cannabis Cannabinoid Res       Date:  2021-06-04

9.  Finding cannabinoids in hair does not prove cannabis consumption.

Authors:  Bjoern Moosmann; Nadine Roth; Volker Auwärter
Journal:  Sci Rep       Date:  2015-10-07       Impact factor: 4.379

Review 10.  E-Cigarettes: A Review of New Trends in Cannabis Use.

Authors:  Christian Giroud; Mariangela de Cesare; Aurélie Berthet; Vincent Varlet; Nicolas Concha-Lozano; Bernard Favrat
Journal:  Int J Environ Res Public Health       Date:  2015-08-21       Impact factor: 3.390
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