Literature DB >> 15733867

Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins.

Krista Ouwehand1, Annemieke J M de Ruijter, Chris van Bree, Huib N Caron, André B P van Kuilenburg.   

Abstract

Histone deacetylase inhibitors (HDACi) have been discovered as potential drugs for cancer treatment. The effect of BL1521, a novel HDACi, on the cell cycle distribution and the induction of apoptosis was investigated in a panel of MYCN single copy and MYCN amplified neuroblastoma cell lines. BL1521 arrested neuroblastoma cells in the G1 phase and induced up to 30% apoptosis. Downregulation of CDK4, upregulation of p21(WAF1/CIP1) and an increase of hypophosphorylated retinoblastoma protein were observed, indicating a possible mechanism for the cell-cycle arrest. BL1521 also induced downregulation of p27, which may underlie the observed induction of apoptosis.

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Year:  2005        PMID： 15733867     DOI： 10.1016/j.febslet.2005.01.058

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model.

Authors:  Thilo S Lange; Yongping Zou; Rakesh K Singh; Kyu K Kim; Katrin Kristjansdottir; Giselle L S Sholler; Laurent Brard
Journal:  Chem Biol Drug Des       Date:  2010-05-11       Impact factor: 2.817

2.  HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process.

Authors:  Linlin Zhang; Ningning Liu; Songbo Xie; Xianfei He; Jun Zhou; Min Liu; Dengwen Li
Journal:  Cancer Biol Ther       Date:  2014       Impact factor: 4.742

3.  The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

Authors:  Anna Scuto; Mark Kirschbaum; Claudia Kowolik; Leo Kretzner; Agnes Juhasz; Peter Atadja; Vinod Pullarkat; Ravi Bhatia; Stephen Forman; Yun Yen; Richard Jove
Journal:  Blood       Date:  2008-03-18       Impact factor: 22.113

4.  Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.

Authors:  Cynthia K Hahn; Kenneth N Ross; Ian M Warrington; Ralph Mazitschek; Cindy M Kanegai; Renee D Wright; Andrew L Kung; Todd R Golub; Kimberly Stegmaier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-07       Impact factor: 11.205

5.  Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Authors:  Leo Kretzner; Anna Scuto; Pamela M Dino; Claudia M Kowolik; Jun Wu; Patrick Ventura; Richard Jove; Stephen J Forman; Yun Yen; Mark H Kirschbaum
Journal:  Cancer Res       Date:  2011-04-18       Impact factor: 12.701

6.  Effect of low doses of actinomycin D on neuroblastoma cell lines.

Authors:  Constanza L Cortes; Sonia R Veiga; Eugènia Almacellas; Javier Hernández-Losa; Joan C Ferreres; Sara C Kozma; Santiago Ambrosio; George Thomas; Albert Tauler
Journal:  Mol Cancer       Date:  2016-01-04       Impact factor: 27.401

Review 7.  Targeting of epigenetic regulators in neuroblastoma.

Authors:  Luz Jubierre; Carlos Jiménez; Eric Rovira; Aroa Soriano; Constantino Sábado; Luis Gros; Anna Llort; Raquel Hladun; Josep Roma; Josep Sánchez de Toledo; Soledad Gallego; Miguel F Segura
Journal:  Exp Mol Med       Date:  2018-04-27       Impact factor: 8.718

8.  Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.

Authors:  Annick Mühlethaler-Mottet; Roland Meier; Marjorie Flahaut; Katia Balmas Bourloud; Katya Nardou; Jean-Marc Joseph; Nicole Gross
Journal:  Mol Cancer       Date:  2008-06-12       Impact factor: 27.401

9.  RuvBL2 is involved in histone deacetylase inhibitor PCI-24781-induced cell death in SK-N-DZ neuroblastoma cells.

Authors:  Qinglei Zhan; Sauna Tsai; Yonghai Lu; Chunmei Wang; Yiuwa Kwan; Saiming Ngai
Journal:  PLoS One       Date:  2013-08-16       Impact factor: 3.240

Review 10.  Cell Proliferation in Neuroblastoma.

Authors:  Laura L Stafman; Elizabeth A Beierle
Journal:  Cancers (Basel)       Date:  2016-01-12       Impact factor: 6.639
  10 in total

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