| Literature DB >> 15733740 |
H Poirier1, I Niot, L Clément, M Guerre-Millo, P Besnard.
Abstract
Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.Entities:
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Year: 2005 PMID： 15733740 DOI： 10.1016/j.biochi.2004.11.006
Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079