BACKGROUND: Recent epidemiological data suggested that there is a relationship between periodontal health and atherosclerotic coronary heart disease. Although hypothetical models were proposed, the exact mechanism of this association has not been clarified. The aim of this study is to investigate whether there is an endothelial dysfunction in patients with chronic periodontitis and, if present, whether recovery is possible with therapy. METHODS: The study groups consisted of 28 patients (mean age: 45.5 +/- 8.6 years) with chronic periodontitis and without any atherosclerotic vascular disease, and 26 healthy controls (mean age: 43.7 +/- 6.8 years). Cardiovascular risk factors were investigated in both groups. Brachial artery responses to reactive hyperemia (endothelium-dependent dilatation [EDD]) and sublingual nitroglycerin (endothelium-independent dilatation [EID]) were measured using high-resolution vascular ultrasound in both groups. Measurements were taken before and after initial periodontal therapy in the periodontal patients. RESULTS: There was no significant difference between the groups with regard to cardiovascular risk factors. In the baseline measurements, EDD and EID were significantly impaired in patients with chronic periodontitis when compared with the controls (8.4% +/- 4.0% versus 19.4% +/- 8.1%, P<0.0001; 13.3% +/- 6.3% versus 29.5% +/- 10.0%, P<0.0001 for EDD and EID, respectively). After non-surgical periodontal therapy, EDD and EID improved significantly (from 8.4% +/- 4.0% to 17.7% +/- 5.7%, P<0.0001; and from 13.3% +/- 6.3% to 24.9% +/- 7.3%, P<0.0001 for FMD and EID, respectively). The EDD and EID changes in the controls were insignificant. CONCLUSION: This study showed that endothelial functions were impaired in patients with chronic periodontitis and that they improve following initial periodontal therapy.
BACKGROUND: Recent epidemiological data suggested that there is a relationship between periodontal health and atherosclerotic coronary heart disease. Although hypothetical models were proposed, the exact mechanism of this association has not been clarified. The aim of this study is to investigate whether there is an endothelial dysfunction in patients with chronic periodontitis and, if present, whether recovery is possible with therapy. METHODS: The study groups consisted of 28 patients (mean age: 45.5 +/- 8.6 years) with chronic periodontitis and without any atherosclerotic vascular disease, and 26 healthy controls (mean age: 43.7 +/- 6.8 years). Cardiovascular risk factors were investigated in both groups. Brachial artery responses to reactive hyperemia (endothelium-dependent dilatation [EDD]) and sublingual nitroglycerin (endothelium-independent dilatation [EID]) were measured using high-resolution vascular ultrasound in both groups. Measurements were taken before and after initial periodontal therapy in the periodontal patients. RESULTS: There was no significant difference between the groups with regard to cardiovascular risk factors. In the baseline measurements, EDD and EID were significantly impaired in patients with chronic periodontitis when compared with the controls (8.4% +/- 4.0% versus 19.4% +/- 8.1%, P<0.0001; 13.3% +/- 6.3% versus 29.5% +/- 10.0%, P<0.0001 for EDD and EID, respectively). After non-surgical periodontal therapy, EDD and EID improved significantly (from 8.4% +/- 4.0% to 17.7% +/- 5.7%, P<0.0001; and from 13.3% +/- 6.3% to 24.9% +/- 7.3%, P<0.0001 for FMD and EID, respectively). The EDD and EID changes in the controls were insignificant. CONCLUSION: This study showed that endothelial functions were impaired in patients with chronic periodontitis and that they improve following initial periodontal therapy.
Authors: Panos N Papapanou; Michael H Sedaghatfar; Ryan T Demmer; Dana L Wolf; Jun Yang; Georg A Roth; Romanita Celenti; Paul B Belusko; Evanthia Lalla; Paul Pavlidis Journal: J Clin Periodontol Date: 2007-09 Impact factor: 8.728
Authors: Steven Offenbacher; James D Beck; Kevin Moss; Luisito Mendoza; David W Paquette; David A Barrow; David J Couper; Dawn D Stewart; Karen L Falkner; Susan P Graham; Sara Grossi; John C Gunsolley; Theresa Madden; Gerardo Maupome; Maurizio Trevisan; Thomas E Van Dyke; Robert J Genco Journal: J Periodontol Date: 2009-02 Impact factor: 6.993
Authors: Meggan M H Wehmeyer; Abhijit V Kshirsagar; Silvana P Barros; James D Beck; Kevin L Moss; John S Preisser; Steven Offenbacher Journal: Am J Kidney Dis Date: 2012-12-20 Impact factor: 8.860
Authors: Dara M Shearer; W Murray Thomson; Claire M Cameron; Sandhya Ramrakha; Graham Wilson; Tien Yin Wong; Michael J A Williams; Rachael McLean; Reremoana Theodore; Richie Poulton Journal: Community Dent Oral Epidemiol Date: 2018-08-30 Impact factor: 3.383
Authors: Małgorzata Radwan-Oczko; Aleksander Jaworski; Irena Duś; Tomasz Plonek; Malgorzata Szulc; Wojciech Kustrzycki Journal: Virulence Date: 2014-04-04 Impact factor: 5.882
Authors: Moritz Kebschull; Manuela Haupt; Søren Jepsen; James Deschner; Georg Nickenig; Nikos Werner Journal: PLoS One Date: 2013-01-23 Impact factor: 3.240