BACKGROUND: Anemia is associated with disease severity and prognosis for patients with congestive heart failure (CHF). It is unknown whether anemia is associated with the development of new-onset CHF in the elderly. METHODS AND RESULTS: This retrospective longitudinal cohort study used the Medicare 5% database. In the incident analysis, the study sample comprised subjects without CHF in 1999 (n = 1,063,495); the main exposure variable evaluated was the presence or absence of anemia in 1999; and the primary study outcome was the occurrence of new-onset CHF. The prevalence of chronic anemia and CHF in 1999 was 5.0% and 9.9%, respectively. The incidence of new-onset CHF in 2000 in those with and those without anemia in 1999 was 12.3% and 5.9%, respectively, corresponding to an adjusted hazard ratio of 1.29 ( P < .001), a value intermediate between the hazard ratios of 1.13 ( P < .001), and 1.76 ( P < .001) associated with hypertension and atherosclerotic heart disease, respectively. Anemia also was associated with death in the year after new-onset CHF (adjusted hazard ratio, 1.28; P < .001). CONCLUSION: Anemia in the Medicare population is associated with the diagnosis and prognosis of new-onset CHF.
BACKGROUND:Anemia is associated with disease severity and prognosis for patients with congestive heart failure (CHF). It is unknown whether anemia is associated with the development of new-onset CHF in the elderly. METHODS AND RESULTS: This retrospective longitudinal cohort study used the Medicare 5% database. In the incident analysis, the study sample comprised subjects without CHF in 1999 (n = 1,063,495); the main exposure variable evaluated was the presence or absence of anemia in 1999; and the primary study outcome was the occurrence of new-onset CHF. The prevalence of chronic anemia and CHF in 1999 was 5.0% and 9.9%, respectively. The incidence of new-onset CHF in 2000 in those with and those without anemia in 1999 was 12.3% and 5.9%, respectively, corresponding to an adjusted hazard ratio of 1.29 ( P < .001), a value intermediate between the hazard ratios of 1.13 ( P < .001), and 1.76 ( P < .001) associated with hypertension and atherosclerotic heart disease, respectively. Anemia also was associated with death in the year after new-onset CHF (adjusted hazard ratio, 1.28; P < .001). CONCLUSION:Anemia in the Medicare population is associated with the diagnosis and prognosis of new-onset CHF.
Authors: Donald S Silverberg; Dov Wexler; Adrian Iaina; Shoshana Steinbruch; Y Wollman; Doron Schwartz Journal: Int Urol Nephrol Date: 2006 Impact factor: 2.370
Authors: Louise Emilsson; Xabier García-Albéniz; Roger W Logan; Ellen C Caniglia; Mette Kalager; Miguel A Hernán Journal: JAMA Oncol Date: 2018-01-01 Impact factor: 31.777
Authors: S Heleen Binnenmars; Georgette E Hoogslag; Stanley M H Yeung; Frank P Brouwers; Stephan J L Bakker; Wiek H van Gilst; Ron T Gansevoort; Gerjan Navis; Adriaan A Voors; Martin H de Borst Journal: J Am Heart Assoc Date: 2022-07-25 Impact factor: 6.106