Literature DB >> 15731283

Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production.

R Travis Taylor1, Wade A Bresnahan.   

Abstract

The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMV infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMV infection, identifying IE2 as an IFN-beta antagonist.

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Year:  2005        PMID： 15731283      PMCID： PMC1075717          DOI： 10.1128/JVI.79.6.3873-3877.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

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  60 in total

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