PURPOSE: To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS: In total, 34 subjects with unilateral left (n = 15) or right (n = 19) TLE were compared with 65 healthy controls. Regions of interest included the ipsilateral and contralateral hippocampus as well as temporal, frontal, parietal, and occipital lobe gray and white matter. Clinical markers of neurodevelopmental insult (initial precipitating insult, early age of recurrent seizures) and chronicity of epilepsy (epilepsy duration, estimated number of lifetime generalized seizures) were related to magnetic resonance (MR) volume abnormalities. RESULTS: Quantitative MR abnormalities extend beyond the ipsilateral hippocampus and temporal lobe with extratemporal (frontal and parietal lobe) reductions in cerebral white matter, especially ipsilateral but also contralateral to the side of seizure onset. Volumetric abnormalities in ipsilateral hippocampus and bilateral cerebral white matter are associated with factors related to both the onset and the chronicity of the patients' epilepsy. CONCLUSIONS: These cross-sectional findings support the view that volumetric abnormalities in chronic TLE are associated with a combination of neurodevelopmental and progressive effects, characterized by a prominent disruption in ipsilateral hippocampus and neural connectivity (i.e., white matter volume loss) that extends beyond the temporal lobe, affecting both ipsilateral and contralateral hemispheres.
PURPOSE: To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS: In total, 34 subjects with unilateral left (n = 15) or right (n = 19) TLE were compared with 65 healthy controls. Regions of interest included the ipsilateral and contralateral hippocampus as well as temporal, frontal, parietal, and occipital lobe gray and white matter. Clinical markers of neurodevelopmental insult (initial precipitating insult, early age of recurrent seizures) and chronicity of epilepsy (epilepsy duration, estimated number of lifetime generalized seizures) were related to magnetic resonance (MR) volume abnormalities. RESULTS: Quantitative MR abnormalities extend beyond the ipsilateral hippocampus and temporal lobe with extratemporal (frontal and parietal lobe) reductions in cerebral white matter, especially ipsilateral but also contralateral to the side of seizure onset. Volumetric abnormalities in ipsilateral hippocampus and bilateral cerebral white matter are associated with factors related to both the onset and the chronicity of the patients' epilepsy. CONCLUSIONS: These cross-sectional findings support the view that volumetric abnormalities in chronic TLE are associated with a combination of neurodevelopmental and progressive effects, characterized by a prominent disruption in ipsilateral hippocampus and neural connectivity (i.e., white matter volume loss) that extends beyond the temporal lobe, affecting both ipsilateral and contralateral hemispheres.
Authors: Claus Reinsberger; Naoaki Tanaka; Andrew J Cole; Jong Woo Lee; Barbara A Dworetzky; Edward B Bromfield; Lorie Hamiwka; Blaise F Bourgeois; Alexandra J Golby; Joseph R Madsen; Steven M Stufflebeam Journal: Neuroimage Date: 2010-05-21 Impact factor: 6.556
Authors: N Erkut Kucukboyaci; H M Girard; D J Hagler; J Kuperman; E S Tecoma; V J Iragui; E Halgren; C R McDonald Journal: J Int Neuropsychol Soc Date: 2011-10-12 Impact factor: 2.892
Authors: Christopher C Stewart; H Randall Griffith; Ozioma C Okonkwo; Roy C Martin; Robert K Knowlton; Elizabeth J Richardson; Bruce P Hermann; Michael Seidenberg Journal: Brain Cogn Date: 2008-07-02 Impact factor: 2.310
Authors: Dalin T Pulsipher; Michael Seidenberg; Jared J Morton; Elizabeth Geary; Joy Parrish; Bruce Hermann Journal: Epilepsy Behav Date: 2007-11 Impact factor: 2.937
Authors: Dalin T Pulsipher; Michael Seidenberg; Leslie Guidotti; Victoria N Tuchscherer; Jared Morton; Raj D Sheth; Bruce Hermann Journal: Epilepsia Date: 2009-01-17 Impact factor: 5.864
Authors: Carrie R McDonald; Donald J Hagler; Mazyar E Ahmadi; Evelyn Tecoma; Vicente Iragui; Anders M Dale; Eric Halgren Journal: Epilepsy Res Date: 2008-03-21 Impact factor: 3.045