Literature DB >> 15730519

Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus.

J-W Hur1, H D Shin, B L Park, L H Kim, S-Y Kim, S-C Bae.   

Abstract

Mammalian Toll-like receptors (TLR) play an important role in both adaptive immunity and innate immunity. Genetic variations within TLR genes are known to be associated with a variety of inflammatory and infectious diseases. TLR9 is potentially associated with autoimmune diseases, because it participates in the production of pro-inflammatory cytokines and the maturation of dendritic cells. We investigated the association of four TLR9 gene polymorphisms (-1486 T>C, -1237 C>T, +1174 A>G and +2848 G>A) with the susceptibility to systemic lupus erythematosus (SLE) and related phenotypes in 680 Korean people (350 SLE patients and 330 controls). TLR9 gene polymorphisms were not significantly associated with the susceptibility to SLE and related phenotypes.

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Year:  2005        PMID： 15730519     DOI： 10.1111/j.1399-0039.2005.00374.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  26 in total

1.  Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan.

Authors:  Chung-Ming Huang; Po-Hao Huang; Chi-Lan Chen; Ying-Ju Lin; Chang-Hai Tsai; Wen-Liang Huang; Fuu-Jen Tsai
Journal:  Rheumatol Int       Date:  2011-04-17       Impact factor: 2.631

2.  TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.

Authors:  Nadia A Sam-Agudu; Jennifer A Greene; Robert O Opoka; James W Kazura; Michael J Boivin; Peter A Zimmerman; Melissa A Riedesel; Tracy L Bergemann; Lisa A Schimmenti; Chandy C John
Journal:  Am J Trop Med Hyg       Date:  2010-04       Impact factor: 2.345

Review 3.  The role of toll-like receptors in systemic lupus erythematosus.

Authors:  Adeeb H Rahman; Robert A Eisenberg
Journal:  Springer Semin Immunopathol       Date:  2006-09-19

Review 4.  TLR7 and TLR9 in SLE: when sensing self goes wrong.

Authors:  T Celhar; R Magalhães; A-M Fairhurst
Journal:  Immunol Res       Date:  2012-09       Impact factor: 2.829

Review 5.  Targeting Toll-like receptors for treatment of SLE.

Authors:  Christopher G Horton; Zi-jian Pan; A Darise Farris
Journal:  Mediators Inflamm       Date:  2010-09-19       Impact factor: 4.711

6.  A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

Authors:  Andriy V Kubarenko; Satish Ranjan; Anna Rautanen; Tara C Mills; Sunny Wong; Fredrik Vannberg; Michael Neumaier; Isabelle Bekeredjian-Ding; Adrian V S Hill; Parviz Ahmad-Nejad; Alexander N R Weber
Journal:  J Biol Chem       Date:  2010-09-14       Impact factor: 5.157

7.  Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.

Authors:  Wen-Ling Liao; Rong-Hsing Chen; Hui-Ju Lin; Yu-Huei Liu; Wen-Chi Chen; Yuhsin Tsai; Lei Wan; Fuu-Jen Tsai
Journal:  BMC Med Genet       Date:  2010-11-05       Impact factor: 2.103

8.  Associations of genetic polymorphisms of TLR5, TLR9 and transduction molecules in MyD88 signaling pathway with systemic lupus erythematosus in Zhuang and Han ethnics of Guangxi province, China.

Authors:  Si-Jian Wen; Fei-Yun Wu; Ling Fang; Hui Liu; Wen-Jun Zheng; You-Kun Lin
Journal:  Int J Clin Exp Med       Date:  2015-05-15

9.  Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese.

Authors:  Chang-Juan Xu; Wen-Hui Zhang; Hai-Feng Pan; Xiang-Pei Li; Jian-Hua Xu; Dong-Qing Ye
Journal:  Mol Biol Rep       Date:  2009-01-07       Impact factor: 2.316

Review 10.  Toll-like receptors and NOD-like receptors in rheumatic diseases.

Authors:  William J McCormack; Andrew E Parker; Luke A O'Neill
Journal:  Arthritis Res Ther       Date:  2009-10-14       Impact factor: 5.156
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