Literature DB >> 15730397

Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue.

Y Hosokawa1, T Nakanishi, D Yamaguchi, H Nakae, T Matsuo.   

Abstract

The regulatory role of chemokines and chemokine receptors on specific leucocyte recruitment into periodontal diseased tissue is poorly characterized. We observed that leucocytes infiltrating inflamed gingival tissue expressed marked levels of CX3CR1. In periodontal diseased tissue, the expression of fractalkine and CX3CR1 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and further, fractalkine was distributed mainly on endothelial cells, as shown by immunohistochemistry. Moreover, we can detect CX3CR1-expressing cells infiltrated in periodontal diseased tissue by immunohistochemical staining. Furthermore, fractalkine production by human umbilical vein endothelial cells (HUVEC) was up-regulated by pathogen-associated molecular patterns (PAMPs), including Porphyromonas gingivalis lipopolysaccharide (LPS). Thus, these findings suggested that CX3CR1 and the corresponding chemokine, fractalkine may have an important regulatory role on specific leucocyte migration into inflamed periodontal tissue.

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Year:  2005        PMID： 15730397      PMCID： PMC1809327          DOI： 10.1111/j.1365-2249.2005.02675.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  24 in total

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Journal:  J Immunol       Date:  2000-04-15       Impact factor: 5.422

Review 2.  The role of chemokine receptors in primary, effector, and memory immune responses.

Authors:  F Sallusto; C R Mackay; A Lanzavecchia
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3.  Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing.

Authors:  O Takeichi; J Haber; T Kawai; D J Smith; I Moro; M A Taubman
Journal:  J Dent Res       Date:  2000-08       Impact factor: 6.116

Review 4.  Chemokines in immunity.

Authors:  O Yoshie; T Imai; H Nomiyama
Journal:  Adv Immunol       Date:  2001       Impact factor: 3.543

5.  Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses.

Authors:  P Fraticelli; M Sironi; G Bianchi; D D'Ambrosio; C Albanesi; A Stoppacciaro; M Chieppa; P Allavena; L Ruco; G Girolomoni; F Sinigaglia; A Vecchi; A Mantovani
Journal:  J Clin Invest       Date:  2001-05       Impact factor: 14.808

6.  Expression and regulation of chemokine receptors in human natural killer cells.

Authors:  M Inngjerdingen; B Damaj; A A Maghazachi
Journal:  Blood       Date:  2001-01-15       Impact factor: 22.113

7.  Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human.

Authors:  A Foussat; A Coulomb-L'Hermine; J Gosling; R Krzysiek; I Durand-Gasselin; T Schall; A Balian; Y Richard; P Galanaud; D Emilie
Journal:  Eur J Immunol       Date:  2000-01       Impact factor: 5.532

Review 8.  Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption.

Authors:  M A Taubman; T Kawai
Journal:  Crit Rev Oral Biol Med       Date:  2001

9.  CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

Authors:  F Liao; R L Rabin; C S Smith; G Sharma; T B Nutman; J M Farber
Journal:  J Immunol       Date:  1999-01-01       Impact factor: 5.422

10.  Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.

Authors:  A M Fong; L A Robinson; D A Steeber; T F Tedder; O Yoshie; T Imai; D D Patel
Journal:  J Exp Med       Date:  1998-10-19       Impact factor: 14.307
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  6 in total

1.  CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts.

Authors:  Y Hosokawa; I Hosokawa; K Ozaki; H Nakae; T Matsuo
Journal:  Clin Exp Immunol       Date:  2007-04-25       Impact factor: 4.330

2.  Adrenomedullin suppresses tumour necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts.

Authors:  I Hosokawa; Y Hosokawa; K Ozaki; H Nakae; T Matsuo
Journal:  Clin Exp Immunol       Date:  2008-04-24       Impact factor: 4.330

3.  Fractalkine functions as a chemoattractant for osteoarthritis synovial fibroblasts and stimulates phosphorylation of mitogen-activated protein kinases and Akt.

Authors:  K Klosowska; M V Volin; N Huynh; K K Chong; M M Halloran; J M Woods
Journal:  Clin Exp Immunol       Date:  2009-03-11       Impact factor: 4.330

4.  Correlation of serum cytokines, chemokines, growth factors and enzymes with periodontal disease parameters.

Authors:  Jeneen Panezai; Ambereen Ghaffar; Mohammad Altamash; Karl-Gösta Sundqvist; Per-Erik Engström; Anders Larsson
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240

Review 5.  HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation.

Authors:  Samantha E Heron; Shokrollah Elahi
Journal:  Front Immunol       Date:  2017-03-07       Impact factor: 7.561

6.  Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.

Authors:  Yihong Wan; Ronald M Evans
Journal:  J Mol Endocrinol       Date:  2009-10-22       Impact factor: 5.098
  6 in total

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