Literature DB >> 15730333

Efficient conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-one to pyrimidines via PyBroP-mediated coupling.

Fu-An Kang1, Jason Kodah, Qunying Guan, Xiaobing Li, William V Murray.   

Abstract

An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles, which provides a readily accessible multifunctionalized pyrimidine template for diversity-oriented synthesis.

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Year:  2005        PMID： 15730333     DOI： 10.1021/jo040281j

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

1.  Synthetic utility of an isolable nucleoside phosphonium salt.

Authors:  Suyeal Bae; Mahesh K Lakshman
Journal:  Org Lett       Date:  2008-05-13       Impact factor: 6.005

2.  Discovery and lead identification of quinazoline-based BRD4 inhibitors.

Authors:  Shyh-Ming Yang; Daniel J Urban; Makoto Yoshioka; Jeffrey W Strovel; Steven Fletcher; Amy Q Wang; Xin Xu; Pranav Shah; Xin Hu; Matthew D Hall; Ajit Jadhav; David J Maloney
Journal:  Bioorg Med Chem Lett       Date:  2018-08-31       Impact factor: 2.823

3.  One-pot etherification of purine nucleosides and pyrimidines.

Authors:  Hari Prasad Kokatla; Mahesh K Lakshman
Journal:  Org Lett       Date:  2010-10-15       Impact factor: 6.005

4.  Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies.

Authors:  Anjila Kumari; Tara Jaiswal; Vinay Kumar; Neha Hura; Gulshan Kumar; Neerupudi Kishore Babu; Ayan Acharya; Pradyot K Roy; Sankar K Guchhait; Sushma Singh
Journal:  RSC Med Chem       Date:  2022-01-06

5.  Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines.

Authors:  Jovana Muškinja; Nenad Janković; Zoran Ratković; Goran Bogdanović; Zorica Bugarčić
Journal:  Mol Divers       Date:  2016-01-30       Impact factor: 2.943

6.  Aerobic copper-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidine-1H-2-thiones with alcohols.

Authors:  Jihong Lee; Yujeong Kwon; Dong-Chan Lee; Jeong-Hun Sohn
Journal:  RSC Adv       Date:  2021-11-17       Impact factor: 3.361
  6 in total

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