Literature DB >> 15730301

A novel and highly regioselective approach to 5-methoxy-6-substituted-3-sulfonyl-delta-enlactams from 5-methoxy-3-sulfonyl glutarimide: synthesis of cis-2-substituted-3-piperidinols.

Min-Ruei Tsai1, Bo-Fong Chen, Chih-Ching Cheng, Nein-Chen Chang.   

Abstract

A convenient method for the preparation of 5-methoxy-6-substituted-3-sulfonyl-delta-enlactams via regioselective nucleophilic addition to 5-methoxy-3-sulfonyl glutarimide is described. Formal syntheses of L-733,060, CP-99,994, and cassine are also reported.

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Year:  2005        PMID： 15730301     DOI： 10.1021/jo048073e

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

Authors:  Renzhong Fu; Baoguo Zhao; Yian Shi
Journal:  J Org Chem       Date:  2009-10-02       Impact factor: 4.354

2.  Asymmetric Synthesis of (+)-Iso-6-Cassine via Stereoselective Intramolecular Amidomercuration.

Authors:  Satwinder Singh; Om V Singh; Hyunsoo Han
Journal:  Tetrahedron Lett       Date:  2007-11-19       Impact factor: 2.415
  2 in total

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