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Literature DB >> 15728935

Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance.

Svetolik Djurkovic¹, Jutta M Loeffler, Vincent A Fischetti.

Abstract

A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.

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Year: 2005 PMID： 15728935 PMCID： PMC549239 DOI： 10.1128/AAC.49.3.1225-1228.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

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4. The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae.

Authors: S R Filipe; E Severina; A Tomasz
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8. Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia.

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Review 10. Bacteriophage lysins as effective antibacterials.

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Journal: Curr Opin Microbiol Date: 2008-10-14 Impact factor: 7.934