Literature DB >> 15728931

Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.

Hsiu-Jung Lo1, Jang-Shiun Wang, Chih-Yang Lin, Chia-Geun Chen, Ting-Yin Hsiao, Chia-Tung Hsu, Chia-Li Su, Ming-Ji Fann, Yu-Tai Ching, Yun-Liang Yang.   

Abstract

The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.

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Year:  2005        PMID： 15728931      PMCID： PMC549285          DOI： 10.1128/AAC.49.3.1213-1215.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes.

Authors:  L Diatchenko; S Lukyanov; Y F Lau; P D Siebert
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

2.  The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity.

Authors:  D C Lamb; D E Kelly; W H Schunck; A Z Shyadehi; M Akhtar; D J Lowe; B C Baldwin; S L Kelly
Journal:  J Biol Chem       Date:  1997-02-28       Impact factor: 5.157

3.  Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

Authors:  Patrick Marichal; Luc Koymans; Staf Willemsens; Danny Bellens; Peter Verhasselt; Walter Luyten; Marcel Borgers; Frans C S Ramaekers; Frank C Odds; Hugo Vanden Bossche
Journal:  Microbiology       Date:  1999-10       Impact factor: 2.777

Review 4.  Mechanisms and clinical impact of antifungal drug resistance.

Authors:  H Vanden Bossche; D W Warnock; B Dupont; D Kerridge; S Sen Gupta; L Improvisi; P Marichal; F C Odds; F Provost; O Ronin
Journal:  J Med Vet Mycol       Date:  1994

Review 5.  Molecular basis of resistance to azole antifungals.

Authors:  Antonella Lupetti; Romano Danesi; Mario Campa; Mario Del Tacca; Steven Kelly
Journal:  Trends Mol Med       Date:  2002-02       Impact factor: 11.951

6.  Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia.

Authors:  F S Nolte; T Parkinson; D J Falconer; S Dix; J Williams; C Gilmore; R Geller; J R Wingard
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

7.  Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.

Authors:  Dominique Sanglard; Françoise Ischer; Tania Parkinson; Derek Falconer; Jacques Bille
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

8.  Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.

Authors:  Dominique Sanglard; Françoise Ischer; Oscar Marchetti; José Entenza; Jacques Bille
Journal:  Mol Microbiol       Date:  2003-05       Impact factor: 3.501

9.  [Antifungal susceptibility of yeasts by Etest. Comparison of 3 media].

Authors:  Cecilia Tapia; Eugenia León; Elizabeth Palavecino
Journal:  Rev Med Chil       Date:  2003-03       Impact factor: 0.553

10.  Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations.

Authors:  A M Gillum; E Y Tsay; D R Kirsch
Journal:  Mol Gen Genet       Date:  1984
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  9 in total

1.  Regulatory Role of ERG3 and Efg1 in Azoles-Resistant Strains of Candida albicans Isolated from Patients Diagnosed with Vulvovaginal Candidiasis.

Authors:  Wenli Feng; Jing Yang; Zhiqin Xi; Ying Ji; Xin Zhu; Lu Yang; Yan Ma
Journal:  Indian J Microbiol       Date:  2019-11-02       Impact factor: 2.461

2.  Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.

Authors:  Kang Xiong; Chang Su; Qiangqiang Sun; Yang Lu
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

3.  Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence.

Authors:  Hui-Ching Ko; Ting-Yin Hsiao; Chiung-Tong Chen; Yun-Liang Yang
Journal:  J Microbiol       Date:  2013-06-28       Impact factor: 3.422

Review 4.  Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans.

Authors:  Subhrajit Biswas; Patrick Van Dijck; Asis Datta
Journal:  Microbiol Mol Biol Rev       Date:  2007-06       Impact factor: 11.056

Review 5.  Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development.

Authors:  Małgorzata Bondaryk; Wiesław Kurzątkowski; Monika Staniszewska
Journal:  Postepy Dermatol Alergol       Date:  2013-10-30       Impact factor: 1.837

Review 6.  Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans.

Authors:  Saif Hameed; Zeeshan Fatima
Journal:  Int J Microbiol       Date:  2013-09-16

7.  Role of Virulence Determinants in Candida albicans' Resistance to Novel 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone.

Authors:  Monika Staniszewska; Małgorzata Bondaryk; Zbigniew Ochal
Journal:  J Fungi (Basel)       Date:  2017-06-24

Review 8.  Progress in the biological function of alpha-enolase.

Authors:  Hong Ji; Jianfa Wang; Jingru Guo; Yue Li; Shuai Lian; Wenjin Guo; Huanmin Yang; Fanzhi Kong; Li Zhen; Li Guo; Yanzhi Liu
Journal:  Anim Nutr       Date:  2016-03-02

Review 9.  Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents.

Authors:  Giselle C de Oliveira Santos; Cleydlenne C Vasconcelos; Alberto J O Lopes; Maria do S de Sousa Cartágenes; Allan K D B Filho; Flávia R F do Nascimento; Ricardo M Ramos; Emygdia R R B Pires; Marcelo S de Andrade; Flaviane M G Rocha; Cristina de Andrade Monteiro
Journal:  Front Microbiol       Date:  2018-07-03       Impact factor: 5.640
  9 in total

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