Literature DB >> 15728929

Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect.

William Stubbings1, Julieanne Bostock, Eileen Ingham, Ian Chopra.   

Abstract

The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established.

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Year:  2005        PMID： 15728929      PMCID： PMC549255          DOI： 10.1128/AAC.49.3.1206-1208.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.

Authors:  M C Sulavik; C Houseweart; C Cramer; N Jiwani; N Murgolo; J Greene; B DiDomenico; K J Shaw; G H Miller; R Hare; G Shimer
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

2.  Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid.

Authors:  A J O'Neill; J M Bostock; A Morais Moita; I Chopra
Journal:  J Antimicrob Chemother       Date:  2002-12       Impact factor: 5.790

3.  Correlation between bactericidal activity and postantibiotic effect for five antibiotics with different mechanisms of action.

Authors:  R C Li; S W Lee; C H Kong
Journal:  J Antimicrob Chemother       Date:  1997-07       Impact factor: 5.790

4.  Postantibiotic suppression of bacterial growth.

Authors:  R W Bundtzen; A U Gerber; D L Cohn; W A Craig
Journal:  Rev Infect Dis       Date:  1981 Jan-Feb

5.  Evidence for more than one mechanism of plasmid-determined tetracycline resistance in Escherichia coli.

Authors:  S W Shales; I Chopra; P R Ball
Journal:  J Gen Microbiol       Date:  1980-11

6.  Molecular investigation of the postantibiotic effects of clarithromycin and erythromycin on Staphylococcus aureus cells.

Authors:  W S Champney; C L Tober
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

7.  Studies on the postantibiotic effect and the postantibiotic sub-MIC effect of meropenem.

Authors:  I Odenholt-Tornqvist
Journal:  J Antimicrob Chemother       Date:  1993-06       Impact factor: 5.790

8.  Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli.

Authors:  William J Stubbings; Julieanne M Bostock; Eileen Ingham; Ian Chopra
Journal:  J Antimicrob Chemother       Date:  2004-05-18       Impact factor: 5.790

9.  Persistent acylation of high-molecular-weight penicillin-binding proteins by penicillin induces the postantibiotic effect in Streptococcus pyogenes.

Authors:  S Yan; G A Bohach; D L Stevens
Journal:  J Infect Dis       Date:  1994-09       Impact factor: 5.226
  9 in total
  3 in total

Review 1.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

2.  Five-minute exposure to caspofungin results in prolonged postantifungal effects and eliminates the paradoxical growth of Candida albicans.

Authors:  Ryan K Shields; M Hong Nguyen; Ellen G Press; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2011-05-02       Impact factor: 5.191

3.  In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.

Authors:  Gregory T Robertson; Eric J Bonventre; Timothy B Doyle; Qun Du; Leonard Duncan; Timothy W Morris; Eric D Roche; Dalai Yan; A Simon Lynch
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191
  3 in total

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