Literature DB >> 15728921

Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.

C Ying1, A Holy, D Hocková, Z Havlas, E De Clercq, J Neyts.   

Abstract

Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.

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Year:  2005        PMID： 15728921      PMCID： PMC549220          DOI： 10.1128/AAC.49.3.1177-1180.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.

Authors:  Vikas Yadav; Chung K Chu
Journal:  Bioorg Med Chem Lett       Date:  2004-08-16       Impact factor: 2.823

2.  Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication.

Authors:  S K Ladner; M J Otto; C S Barker; K Zaifert; G H Wang; J T Guo; C Seeger; R W King
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

Authors:  Antonín Holý; Ivan Votruba; Milena Masojídková; Graciela Andrei; Robert Snoeck; Lieve Naesens; Erik De Clercq; Jan Balzarini
Journal:  J Med Chem       Date:  2002-04-25       Impact factor: 7.446

4.  Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.

Authors:  C Ying; E De Clercq; W Nicholson; P Furman; J Neyts
Journal:  J Viral Hepat       Date:  2000-03       Impact factor: 3.728

5.  The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNA.

Authors:  S K Ladner; T J Miller; R W King
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

6.  Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

Authors:  J Balzarini; A Holy; J Jindrich; L Naesens; R Snoeck; D Schols; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

7.  Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.

Authors:  J Balzarini; S Aquaro; C F Perno; M Witvrouw; A Holý; E De Clercq
Journal:  Biochem Biophys Res Commun       Date:  1996-02-15       Impact factor: 3.575

8.  5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.

Authors:  Dana Hocková; Antonín Holý; Milena Masojídková; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Journal:  J Med Chem       Date:  2003-11-06       Impact factor: 7.446

9.  Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.

Authors:  J Balzarini; C Pannecouque; E De Clercq; S Aquaro; C-F Perno; H Egberink; A Holý
Journal:  Antimicrob Agents Chemother       Date:  2002-07       Impact factor: 5.191

Review 10.  Phosphonomethoxyalkyl analogs of nucleotides.

Authors:  Antonín Holy
Journal:  Curr Pharm Des       Date:  2003       Impact factor: 3.116
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  8 in total

1.  In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.

Authors:  M N Brunelle; J Lucifora; J Neyts; S Villet; A Holy; C Trepo; F Zoulim
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

2.  The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.

Authors:  Brian D Herman; Ivan Votruba; Antonin Holy; Nicolas Sluis-Cremer; Jan Balzarini
Journal:  J Biol Chem       Date:  2010-02-17       Impact factor: 5.157

3.  Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.

Authors:  Minyi Shi; Xin Wang; Erik De Clercq; Sonshin Takao; Masanori Baba
Journal:  Antimicrob Agents Chemother       Date:  2007-04-30       Impact factor: 5.191

4.  Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.

Authors:  Petra Doláková; Martin Dracínský; Milena Masojídková; Veronika Solínová; Václav Kasicka; Antonín Holý
Journal:  Eur J Med Chem       Date:  2008-10-02       Impact factor: 6.514

5.  Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.

Authors:  Roger G Ptak; Philippe A Gallay; Dirk Jochmans; Andrew P Halestrap; Urs T Ruegg; Luke A Pallansch; Michael D Bobardt; Marie-Pierre de Béthune; Johan Neyts; Erik De Clercq; Jean-Maurice Dumont; Pietro Scalfaro; Kamel Besseghir; Roland M Wenger; Brigitte Rosenwirth
Journal:  Antimicrob Agents Chemother       Date:  2008-01-22       Impact factor: 5.191

Review 6.  Overview of Biologically Active Nucleoside Phosphonates.

Authors:  Elisabetta Groaz; Steven De Jonghe
Journal:  Front Chem       Date:  2021-01-08       Impact factor: 5.221

7.  A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity.

Authors:  Jan Balzarini; Graciela Andrei; Emanuela Balestra; Dana Huskens; Christophe Vanpouille; Andrea Introini; Sonia Zicari; Sandra Liekens; Robert Snoeck; Antonín Holý; Carlo-Federico Perno; Leonid Margolis; Dominique Schols
Journal:  PLoS Pathog       Date:  2013-07-25       Impact factor: 6.823

8.  An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids.

Authors:  Petr Jansa; Ondřej Hradil; Ondřej Baszczyňski; Martin Dračínský; Blanka Klepetářová; Antonín Holý; Jan Balzarini; Zlatko Janeba
Journal:  Tetrahedron       Date:  2011-11-19       Impact factor: 2.457
  8 in total

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