Gasser M Hathout1, Roongroj Bhidayasiri. 1. Department of Radiology, Geffen School of Medicine, University of California-Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Abstract
OBJECTIVE: Although gait ataxia is usually associated with cerebellar lesions, we review a less familiar cause. We present three patients with dorsal midbrain lesions and correlate these presentations with recent findings in the functional anatomy of the midbrain. CONCLUSION: We suggest that these lesions involve a well-studied but generally unfamiliar area of the dorsal midbrain known as the mesencephalic locomotor region. More specifically, we hypothesize that involvement of the pedunculopontine nucleus, a major component of the mesencephalic locomotor region, may be at least partially responsible for producing midbrain ataxia.
OBJECTIVE: Although gait ataxia is usually associated with cerebellar lesions, we review a less familiar cause. We present three patients with dorsal midbrain lesions and correlate these presentations with recent findings in the functional anatomy of the midbrain. CONCLUSION: We suggest that these lesions involve a well-studied but generally unfamiliar area of the dorsal midbrain known as the mesencephalic locomotor region. More specifically, we hypothesize that involvement of the pedunculopontine nucleus, a major component of the mesencephalic locomotor region, may be at least partially responsible for producing midbrain ataxia.
Authors: Lucia Maria Sacheli; Laura Zapparoli; Carlo De Santis; Matteo Preti; Catia Pelosi; Nicola Ursino; Alberto Zerbi; Giuseppe Banfi; Eraldo Paulesu Journal: Hum Brain Mapp Date: 2017-07-21 Impact factor: 5.038
Authors: Stephanie M Correa; David W Newstrom; James P Warne; Pierre Flandin; Clement C Cheung; Alexander T Lin-Moore; Andrew A Pierce; Allison W Xu; John L Rubenstein; Holly A Ingraham Journal: Cell Rep Date: 2014-12-24 Impact factor: 9.423