C Detrembleur1, J De Nayer, A van den Hecke. 1. Rehabilitation and Physical Medicine Unit, Université catholique de Louvain, Brussels, Belgium. detrembleur@read.ucl.ac.be
Abstract
OBJECTIVE: To compare the effect of celecoxib vs placebo treatment on clinical and gait variables in knee osteoarthritis (OA) patients; focusing on the efficiency of the locomotor mechanism. STUDY DESIGN: A prospective, randomised, double-blind placebo-controlled trial. PATIENTS: Eight adult patients with painful OA of the knee. OUTCOME MEASURES: Clinical assessment included knee pain assessed by the visual analogue scale, range of knee motion assessed by goniometer, and locomotor function status assessed by a Knee Score Scale. Gait was assessed by means of instrumented analysis including synchronous kinematic, dynamic, electromyographic, and energetic recordings. STATISTICAL ANALYSIS: The effect of treatment on the primary variable, the efficiency of the locomotor mechanism, and on secondary clinical and gait variables was assessed by the Hills and Armitage non-parametric approach. RESULTS:Celecoxib treatment improved the efficiency of the locomotor mechanism significantly. Among the secondary outcome measures assessed, celecoxib treatment improved walking cadence and reduced the knee pain significantly. CONCLUSION: This study shows that celecoxib is effective in improving locomotor function and pain in patients with knee OA.
RCT Entities:
OBJECTIVE: To compare the effect of celecoxib vs placebo treatment on clinical and gait variables in knee osteoarthritis (OA) patients; focusing on the efficiency of the locomotor mechanism. STUDY DESIGN: A prospective, randomised, double-blind placebo-controlled trial. PATIENTS: Eight adult patients with painful OA of the knee. OUTCOME MEASURES: Clinical assessment included knee pain assessed by the visual analogue scale, range of knee motion assessed by goniometer, and locomotor function status assessed by a Knee Score Scale. Gait was assessed by means of instrumented analysis including synchronous kinematic, dynamic, electromyographic, and energetic recordings. STATISTICAL ANALYSIS: The effect of treatment on the primary variable, the efficiency of the locomotor mechanism, and on secondary clinical and gait variables was assessed by the Hills and Armitage non-parametric approach. RESULTS:Celecoxib treatment improved the efficiency of the locomotor mechanism significantly. Among the secondary outcome measures assessed, celecoxib treatment improved walking cadence and reduced the knee pain significantly. CONCLUSION: This study shows that celecoxib is effective in improving locomotor function and pain in patients with knee OA.
Authors: T L Sparling; D Schmitt; C E Miller; F Guilak; T J Somers; F J Keefe; R M Queen Journal: Osteoarthritis Cartilage Date: 2014-04-18 Impact factor: 6.576
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Authors: Francis Trombini-Souza; Marcelo de Maio Nascimento; Tarcísio Fulgêncio Alves da Silva; Rodrigo Cappato de Araújo; Mônica Rodrigues Perracini; Isabel C N Sacco Journal: BMC Geriatr Date: 2020-02-22 Impact factor: 3.921