Literature DB >> 15727881

Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

Kyoko Nakagawa-Goto1, Jiu-Hong Wu, Kenneth F Bastow, Chin-Chung Wu, Kuo-Hsiung Lee.   

Abstract

New analogs of desmosdumotin C (1), in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. Compounds 2-9, 13, and 16 were evaluated in vitro against human tumor cell replication. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.

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Year:  2005        PMID： 15727881     DOI： 10.1016/j.bmc.2004.12.040

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.

Authors:  Kyoko Nakagawa-Goto; Tzu-Hsuan Chen; Chieh-Yu Peng; Kenneth F Bastow; Jiu-Hong Wu; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2007-06-15       Impact factor: 7.446

2.  Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action.

Authors:  Kyoko Nakagawa-Goto; Pei-Chi Wu; Kenneth F Bastow; Shuenn-Chen Yang; Sung-Liang Yu; Hsuan-Yu Chen; Jau-Chen Lin; Masuo Goto; Susan L Morris-Natschke; Pan-Chyr Yang; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2011-01-15       Impact factor: 3.641
  2 in total

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