| Literature DB >> 15727870 |
Sheng Biao Wan1, Kristin R Landis-Piwowar, Deborah J Kuhn, Di Chen, Q Ping Dou, Tak Hang Chan.
Abstract
The structure-activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.Entities:
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Year: 2005 PMID： 15727870 DOI： 10.1016/j.bmc.2004.12.056
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641