| Literature DB >> 15727868 |
V Raja Solomon1, Sunil K Puri, Kumkum Srivastava, S B Katti.
Abstract
This study describes the synthesis of new 4-aminoquinoline derivatives and evaluation of their activity against a chloroquine sensitive strain of P. falciparum in vitro and chloroquine resistant N-67 strain of P. yoelii in vivo. All the analogues were found to form strong complex with hematin and inhibit the beta-hematin formation in vitro. These results suggest that these compounds act on heme polymerization target.Entities:
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Year: 2005 PMID： 15727868 DOI： 10.1016/j.bmc.2004.12.051
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641