BACKGROUND: A standardized instrument is needed to rate the overall severity of chronic hand dermatitis (CHD), in particular during clinical trials. OBJECTIVES: To design and validate a photographic guide. METHODS: Initially, five experts were asked to grade 50 photographs of CHD, first individually, then as a consensus-building group, in order to select the photographs included in the guide. Then, a validation session with 11 different dermatologists evaluating 28 patients was conducted to assess the interrater reliability and test-retest reproducibility of the assessment of disease severity, relying on the photographic guide, on two consecutive days. Patient order was randomized, and only diseased hands were visible to prevent any bias in evaluation. RESULTS: The experts reached a consensus for development of a photographic guide composed of five severity levels and four photographs per severity level. Results of the validation session showed a high level of interrater reliability and test-retest reproducibility. CONCLUSIONS: The photographic guide is a reliable tool for assessing the morphological severity of hand dermatitis, and can be used as part of a comprehensive evaluation of disease in international multicentre clinical trials.
BACKGROUND: A standardized instrument is needed to rate the overall severity of chronic hand dermatitis (CHD), in particular during clinical trials. OBJECTIVES: To design and validate a photographic guide. METHODS: Initially, five experts were asked to grade 50 photographs of CHD, first individually, then as a consensus-building group, in order to select the photographs included in the guide. Then, a validation session with 11 different dermatologists evaluating 28 patients was conducted to assess the interrater reliability and test-retest reproducibility of the assessment of disease severity, relying on the photographic guide, on two consecutive days. Patient order was randomized, and only diseased hands were visible to prevent any bias in evaluation. RESULTS: The experts reached a consensus for development of a photographic guide composed of five severity levels and four photographs per severity level. Results of the validation session showed a high level of interrater reliability and test-retest reproducibility. CONCLUSIONS: The photographic guide is a reliable tool for assessing the morphological severity of hand dermatitis, and can be used as part of a comprehensive evaluation of disease in international multicentre clinical trials.
Authors: Tamara Lund; Esben Meulengrath Flachs; Jennifer Astrup Sørensen; Niels Erik Ebbehøj; Jens Peter Bonde; Tove Agner Journal: Int Arch Occup Environ Health Date: 2019-04-16 Impact factor: 3.015
Authors: Madeleine Dulon; Kathrin Kromark; Christoph Skudlik; Albert Nienhaus Journal: Int Arch Occup Environ Health Date: 2007-12-19 Impact factor: 3.015
Authors: Kristina Sophie Ibler; Gregor B E Jemec; Thomas L Diepgen; Christian Gluud; Jane Lindschou Hansen; Per Winkel; Simon Francis Thomsen; Tove Agner Journal: BMJ Date: 2012-12-12
Authors: Wietske Andrea Christoffers; Pieter-Jan Coenraads; Åke Svensson; Thomas L Diepgen; Janine L Dickinson-Blok; Jun Xia; Hywel C Williams Journal: Cochrane Database Syst Rev Date: 2019-04-26
Authors: Robin F van Gils; Pieter G M van der Valk; Derk Bruynzeel; Pieter J Coenraads; Cécile R L Boot; Willem van Mechelen; Johannes R Anema Journal: BMC Public Health Date: 2009-12-01 Impact factor: 3.295