Literature DB >> 15727465

Transtaganolides A-D: novel metabolites from Thapsia transtagana.

Abderrahmane Saouf1, Francisco M Guerra, Juan J Rubal, F Javier Moreno-Dorado, Mohamed Akssira, Fouad Mellouki, Matías López, Antonio J Pujadas, Zacarías D Jorge, Guillermo M Massanet.   

Abstract

Four novel and unusual C-19 compounds from Thapsia transtagana, named transtaganolides A-D, have been isolated. Their structures were established by physical methods, including X-ray analysis of transtaganolides A and B. This is the first time that a 7-methoxy-4,5-dihydro-3H-oxepin-2-one ring has been found in a natural product. [structure: see text]

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Year:  2005        PMID： 15727465     DOI： 10.1021/ol047421w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.

Authors:  Søren Brøgger Christensen; Henrik Toft Simonsen; Nikolai Engedal; Poul Nissen; Jesper Vuust Møller; Samuel R Denmeade; John T Isaacs
Journal:  Prog Chem Org Nat Prod       Date:  2021

2.  Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.

Authors:  Stefan Paula; Josh Abell; Joel Deye; Christopher Elam; Michael Lape; Justin Purnell; Robert Ratliff; Kelly Sebastian; Jodie Zultowsky; Robert J Kempton
Journal:  Bioorg Med Chem       Date:  2009-08-04       Impact factor: 3.641

3.  Total syntheses of (-)-transtaganolide A, (+)-transtaganolide B, (+)-transtaganolide C, and (-)-transtaganolide D and biosynthetic implications.

Authors:  Hosea M Nelson; Jonny R Gordon; Scott C Virgil; Brian M Stoltz
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-16       Impact factor: 15.336
  3 in total

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