| Literature DB >> 15727461 |
Naidu S Chowdari1, Carlos F Barbas.
Abstract
A catalytic route for enantioselective total synthesis of cell adhesion inhibitor BIRT-377 is described. The quaternary stereocenter was constructed through l-proline-derived, tetrazole-catalyzed direct asymmetric alpha-amination of 3-(4-bromophenyl)-2-methylpropanal with dibenzyl azodicarboxylate. In the course of these studies, a one-pot trifluoro acetylation/selective benzyloxycarbonyl deprotection method was developed. [structure: see text]Entities:
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Year: 2005 PMID： 15727461 DOI： 10.1021/ol047368b
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005