| Literature DB >> 15727436 |
Pierre E Tessier1, Natalie Nguyen, Matthew D Clay, Alex G Fallis.
Abstract
A new strategy for the aryl annulation of cyclic ketones is described. Palladium(0) coupling of a propargyl alcohol with the enol triflate of a ketone and addition of vinylmagnesium chloride generates a triene as a magnesium chelate that may be quenched with an electrophile. In some cases, the triene cyclizes under the reaction conditions. Aromatization is accomplished by exposure to manganese dioxide or dichlorodicyanoquinone (DDQ). [reaction: see text]Entities:
Year: 2005 PMID： 15727436 DOI： 10.1021/ol047602y
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005