The normalization of total clearances for intravenous injection drugs.

There have been reports wherein the total clearance of certain drugs exceeded the blood flow rate when blood concentration data following an intravenous injection was used. It is theoretically unusual that for drugs carried to the tissue by blood, the quantity eliminated is larger than the quantity carried. Nevertheless, the problem about total clearance still needs to be solved. The present paper proposes an equation to ensure that such unusual values do not arise.