| Literature DB >> 15726601 |
Yasunori Nakagawa1, Maki Hasegawa, Morito Kurata, Kouhei Yamamoto, Shinya Abe, Miori Inoue, Tamiko Takemura, Katsuiku Hirokawa, Kenshi Suzuki, Masanobu Kitagawa.
Abstract
Inhibitor of apoptosis protein (IAP)-family proteins suppress apoptotic signaling in normal/neoplastic cells in various settings. To determine the apoptosis-resistant mechanism in adult acute mixed lineage leukemia (AMLL) with biphenotypic blasts responsible for resistance against chemotherapy, the expression levels of IAP-family proteins in AMLL bone marrow cells were analyzed by quantitative RT-PCR. The overall expression levels of IAPs were higher than those in control, AML, and ALL cells. A significant difference for the expression of survivin was observed between AMLL and AML (P <0.05), and differences between AMLL and ALL were significant for the expression of survivin (P <0.05), NAIP (P <0.05), and XIAP (P <0.05). These findings suggest that higher expression of various IAPs is associated with the chemotherapy-resistant nature of this specific type of leukemia.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15726601 DOI： 10.1002/ajh.20285
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047