Literature DB >> 15726184

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Sian M Cooper1, Russell J Cox, John Crosby, Matthew P Crump, Joanne Hothersall, Wanpen Laosripaiboon, Thomas J Simpson, Christopher M Thomas.   

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

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Year:  2005        PMID： 15726184     DOI： 10.1039/b414781b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  RSC Adv       Date:  2016-11-24       Impact factor: 3.361

2.  A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.

Authors:  Daisuke Fukuda; Anthony S Haines; Zhongshu Song; Annabel C Murphy; Joanne Hothersall; Elton R Stephens; Rachel Gurney; Russell J Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

Review 3.  Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.

Authors:  Franziska Hemmerling; Frank Hahn
Journal:  Beilstein J Org Chem       Date:  2016-07-20       Impact factor: 2.883

4.  Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586.

Authors:  Jack A Connolly; Amber Wilson; Malgorzata Macioszek; Zhongshu Song; Luoyi Wang; Hadi H Mohammad; Mukul Yadav; Maura di Martino; Claire E Miller; Joanne Hothersall; Anthony S Haines; Elton R Stephens; Matthew P Crump; Christine L Willis; Thomas J Simpson; Peter J Winn; Christopher M Thomas
Journal:  Sci Rep       Date:  2019-02-07       Impact factor: 4.379

5.  Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics.

Authors:  Luoyi Wang; Zhongshu Song; Paul R Race; James Spencer; Thomas J Simpson; Matthew P Crump; Christine L Willis
Journal:  Chem Sci       Date:  2020-05-09       Impact factor: 9.825
  5 in total

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