| Literature DB >> 15725483 |
Cristina Morerio1, Maura Acquila, Cristina Rosanda, Annamaria Rapella, Elisa Tassano, Concetta Micalizzi, Claudio Panarello.
Abstract
The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4.Entities:
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Year: 2004 PMID： 15725483 DOI： 10.1016/j.leukres.2004.09.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156