| Literature DB >> 15724813 |
Srabasti J Chakravorty1, Alister Craig.
Abstract
Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction and the mechanisms that underlie parasite cytoadherence.Entities:
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Year: 2005 PMID： 15724813 DOI： 10.1016/j.ejcb.2004.09.002
Source DB: PubMed Journal: Eur J Cell Biol ISSN： 0171-9335 Impact factor: 4.492