Literature DB >> 15724174

"Polar patch" proteases as glycopeptiligases.

Katie J Doores1, Benjamin G Davis.   

Abstract

The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%.

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Year:  2004        PMID: 15724174     DOI: 10.1039/b412030b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  Recognition of protein-linked glycans as a determinant of peptidase activity.

Authors:  Ilit Noach; Elizabeth Ficko-Blean; Benjamin Pluvinage; Christopher Stuart; Meredith L Jenkins; Denis Brochu; Nakita Buenbrazo; Warren Wakarchuk; John E Burke; Michel Gilbert; Alisdair B Boraston
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-17       Impact factor: 11.205

2.  SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors.

Authors:  Andrzej Bak; Hana Pizova; Violetta Kozik; Katarina Vorcakova; Jiri Kos; Jakub Treml; Klara Odehnalova; Michal Oravec; Ales Imramovsky; Pavel Bobal; Adam Smolinski; Zdeněk Trávníček; Josef Jampilek
Journal:  Int J Mol Sci       Date:  2019-10-29       Impact factor: 5.923

  2 in total

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