E Miller1, N Andrews, A Grant, J Stowe, B Taylor. 1. Immunisation Division, Public Health Laboratory Service, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK. liz.miller@hpa.org.uk
Abstract
BACKGROUND: MMR vaccine has been reported to cause gait disturbance, and this possible association has been claimed to support the MMR-causes-autism theory. AIMS: To determine whether any association between gait disturbance and MMR vaccination exceeds the age related background rate of gait disturbance, using record linkage and self control case series analyses. METHODS: MMR vaccination records were linked to hospital admission and general practitioner attendance data. An increased rate of gait problems with onset in various intervals in the 60 day period after MMR vaccination was looked for in children aged 12 to <24 months. RESULTS: No evidence of an increased rate of hospital admission or general practice consultations for gait disturbance was found in the putative post-vaccination risk periods. CONCLUSIONS: This study provides no evidence for a causal association between MMR and gait disturbance.
BACKGROUND: MMR vaccine has been reported to cause gait disturbance, and this possible association has been claimed to support the MMR-causes-autism theory. AIMS: To determine whether any association between gait disturbance and MMR vaccination exceeds the age related background rate of gait disturbance, using record linkage and self control case series analyses. METHODS: MMR vaccination records were linked to hospital admission and general practitioner attendance data. An increased rate of gait problems with onset in various intervals in the 60 day period after MMR vaccination was looked for in children aged 12 to <24 months. RESULTS: No evidence of an increased rate of hospital admission or general practice consultations for gait disturbance was found in the putative post-vaccination risk periods. CONCLUSIONS: This study provides no evidence for a causal association between MMR and gait disturbance.
Authors: Steven Hawken; Beth K Potter; Julian Little; Eric I Benchimol; Salah Mahmud; Robin Ducharme; Kumanan Wilson Journal: BMC Med Res Methodol Date: 2016-09-23 Impact factor: 4.615
Authors: Kumanan Wilson; Daniel Rodriguez Duque; Malia S Q Murphy; Steven Hawken; Anne Pham-Huy; Jeffrey Kwong; Shelley L Deeks; Beth K Potter; Natasha S Crowcroft; Dennis E Bulman; Pranesh Chakraborty; Julian Little Journal: Hum Vaccin Immunother Date: 2018-02-26 Impact factor: 3.452