Literature DB >> 15723780

Checkpoint signalling: Mad2 conformers and signal propagation.

Kevin G Hardwick1.   

Abstract

The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores.

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Year:  2005        PMID： 15723780     DOI： 10.1016/j.cub.2005.02.008

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  14 in total

1.  Novel mad2 alleles isolated in a Schizosaccharomyces pombe gamma-tubulin mutant are defective in metaphase arrest activity, but remain functional for chromosome stability in unperturbed mitosis.

Authors:  Yoshie Tange; Osami Niwa
Journal:  Genetics       Date:  2007-02-04       Impact factor: 4.562

2.  The mitotic arrest deficient protein MAD2B interacts with the clathrin light chain A during mitosis.

Authors:  Klaas Medendorp; Lilian Vreede; Jan J M van Groningen; Lisette Hetterschijt; Linda Brugmans; Patrick A M Jansen; Wilhelmina H van den Hurk; Diederik R H de Bruijn; Ad Geurts van Kessel
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

3.  Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.

Authors:  Yusuke Nakano; Toshiyuki Sumi; Masanari Morishita; Takeshi Fukuda; Hiroyuki Nobeyama; Hiroyuki Yoshida; Yoshinari Matsumoto; Tomoyo Yasui; Osamu Ishiko
Journal:  Oncol Lett       Date:  2011-11-15       Impact factor: 2.967

4.  A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint.

Authors:  Gourish Mondal; Rathindra N Baral; Susanta Roychoudhury
Journal:  Biochem J       Date:  2006-06-01       Impact factor: 3.857

Review 5.  Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.

Authors:  Chinthalapally V Rao; Hiroshi Y Yamada; Yixin Yao; Wei Dai
Journal:  Carcinogenesis       Date:  2009-04-16       Impact factor: 4.944

6.  The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression.

Authors:  Li Bie; Gang Zhao; Pui Cheng; Gaelle Rondeau; Steffen Porwollik; Yan Ju; Xiao-Qin Xia; Michael McClelland
Journal:  PLoS One       Date:  2011-10-12       Impact factor: 3.240

Review 7.  Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model.

Authors:  Hongtao Yu
Journal:  J Cell Biol       Date:  2006-04-24       Impact factor: 10.539

8.  The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.

Authors:  Klaas Medendorp; Jan J M van Groningen; Lilian Vreede; Lisette Hetterschijt; Wilhelmina H van den Hurk; Diederik R H de Bruijn; Linda Brugmans; Ad Geurts van Kessel
Journal:  PLoS One       Date:  2009-09-15       Impact factor: 3.240

9.  Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.

Authors:  Marina Mapelli; Fabian V Filipp; Giulia Rancati; Lucia Massimiliano; Luigi Nezi; Gunter Stier; Robert S Hagan; Stefano Confalonieri; Simonetta Piatti; Michael Sattler; Andrea Musacchio
Journal:  EMBO J       Date:  2006-03-09       Impact factor: 11.598

10.  Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.

Authors:  Ashleigh Herriott; Michele Sweeney; Michael Whitaker; Michael Taggart; Jun-Yong Huang
Journal:  Cell Cycle       Date:  2012-11-27       Impact factor: 4.534
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