Literature DB >> 15723168

The role of insulin and IGF-1 signaling in longevity.

M Katic1, C R Kahn.   

Abstract

There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

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Year:  2005        PMID： 15723168     DOI： 10.1007/s00018-004-4297-y

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  53 in total

1.  Stimulation of mechano-growth factor expression by myofibrillar proteins in murine myoblasts and myotubes.

Authors:  Irina V Kravchenko; Vladimir A Furalyov; Vladimir O Popov
Journal:  Mol Cell Biochem       Date:  2011-12-09       Impact factor: 3.396

Review 2.  p53, oxidative stress, and aging.

Authors:  Dongping Liu; Yang Xu
Journal:  Antioxid Redox Signal       Date:  2011-02-07       Impact factor: 8.401

3.  Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration.

Authors:  Warin Krityakiarana; Paul M Zhao; Kevin Nguyen; Fernando Gomez-Pinilla; Naiphinich Kotchabhakdi; Jean de Vellis; Araceli Espinosa-Jeffrey
Journal:  Neurochem Res       Date:  2016-02-17       Impact factor: 3.996

4.  Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

Authors:  Jae Hyung An; Kelly Vranas; Michael Lucke; Hideki Inoue; Naoki Hisamoto; Kunihiro Matsumoto; T Keith Blackwell
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-26       Impact factor: 11.205

Review 5.  Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.

Authors:  Latha Ramalingam; Eunjin Oh; Debbie C Thurmond
Journal:  Cell Mol Life Sci       Date:  2012-10-10       Impact factor: 9.261

6.  Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration.

Authors:  Weiping Qin; Wei Zhao; Lap Ho; Jun Wang; Kenneth Walsh; Sam Gandy; Giulio Maria Pasinetti
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691

7.  Identification of evolutionarily conserved genetic regulators of cellular aging.

Authors:  Gerhard T Laschober; Doris Ruli; Edith Hofer; Christoph Muck; Didac Carmona-Gutierrez; Julia Ring; Eveline Hutter; Christoph Ruckenstuhl; Lucia Micutkova; Regina Brunauer; Angelika Jamnig; Daniela Trimmel; Dietmar Herndler-Brandstetter; Stefan Brunner; Christoph Zenzmaier; Natalie Sampson; Michael Breitenbach; Kai-Uwe Fröhlich; Beatrix Grubeck-Loebenstein; Peter Berger; Matthias Wieser; Regina Grillari-Voglauer; Gerhard G Thallinger; Johannes Grillari; Zlatko Trajanoski; Frank Madeo; Günter Lepperdinger; Pidder Jansen-Dürr
Journal:  Aging Cell       Date:  2010-10-28       Impact factor: 9.304

8.  Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.

Authors:  Seung-Jae Lee; Coleen T Murphy; Cynthia Kenyon
Journal:  Cell Metab       Date:  2009-11       Impact factor: 27.287

Review 9.  The GH/IGF-1 axis in ageing and longevity.

Authors:  Riia K Junnila; John J Kopchick; Edward O List; Darlene E Berryman; John W Murrey
Journal:  Nat Rev Endocrinol       Date:  2013-04-16       Impact factor: 43.330

10.  Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction.

Authors:  T Chiba; H Yamaza; I Shimokawa
Journal:  Curr Genomics       Date:  2007-11       Impact factor: 2.236
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