Kamal E Bani-Hani1. 1. Department of Surgery, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid-Jordan. mailto:banihani60@yahoo.com
Abstract
BACKGROUND: There are controversies regarding the differences in the clinicopathological characteristics of gastric cancer between young and older patients. Our aim was to establish clinicopathological differences between both groups. PATIENTS AND METHODS: Records of all Jordanian patients with gastric adenocarcinoma managed at our hospitals between 1991 and 2001 were reviewed. Patients were divided into two groups according to their age; young patients (<or=40 yr of age; n=17), and older patients (>40 yr of age; n=159). The clinicopathological features and overall survival data for both groups were retrospectively analyzed and compared. RESULTS: In the young group, in comparison with older group, females were more predominant (p=0.049), family history of gastric cancer was more common (p=0.006), proximal location and involvement of the entire stomach were more (p<0.001), and diffuse cancers (65% vs 13%) and poorly differentiated carcinomas (47% vs 26%) were more prevalent. Advanced tumor stage was the same in both groups (65% vs 64%, ns). There was no significant difference in survival between young and old patients (p=0.287). However, age was significantly associated with survival when treated as a continuous variable even after adjusting for the effects of site and stage of tumor on survival. The probability of death was increased by 5.6% with each yr of age. CONCLUSIONS: Special features of gastric cancer differ significantly between young and older age groups. Greater awareness of early-onset gastric cancer is mandatory for detecting cancer early enough so that it is treated successfully.
BACKGROUND: There are controversies regarding the differences in the clinicopathological characteristics of gastric cancer between young and older patients. Our aim was to establish clinicopathological differences between both groups. PATIENTS AND METHODS: Records of all Jordanian patients with gastric adenocarcinoma managed at our hospitals between 1991 and 2001 were reviewed. Patients were divided into two groups according to their age; young patients (<or=40 yr of age; n=17), and older patients (>40 yr of age; n=159). The clinicopathological features and overall survival data for both groups were retrospectively analyzed and compared. RESULTS: In the young group, in comparison with older group, females were more predominant (p=0.049), family history of gastric cancer was more common (p=0.006), proximal location and involvement of the entire stomach were more (p<0.001), and diffuse cancers (65% vs 13%) and poorly differentiated carcinomas (47% vs 26%) were more prevalent. Advanced tumor stage was the same in both groups (65% vs 64%, ns). There was no significant difference in survival between young and old patients (p=0.287). However, age was significantly associated with survival when treated as a continuous variable even after adjusting for the effects of site and stage of tumor on survival. The probability of death was increased by 5.6% with each yr of age. CONCLUSIONS: Special features of gastric cancer differ significantly between young and older age groups. Greater awareness of early-onset gastric cancer is mandatory for detecting cancer early enough so that it is treated successfully.
Authors: D G Huntsman; F Carneiro; F R Lewis; P M MacLeod; A Hayashi; K G Monaghan; R Maung; R Seruca; C E Jackson; C Caldas Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: M Rugge; G Busatto; M Cassaro; Y H Shiao; V Russo; G Leandro; C Avellini; A Fabiano; A Sidoni; A Covacci Journal: Cancer Date: 1999-06-15 Impact factor: 6.860
Authors: Soo-Jeong Cho; Il Ju Choi; Chan Gyoo Kim; Jong Yeul Lee; Myeong-Cherl Kook; Moon-Woo Seong; Sook Ryun Park; Jong Seok Lee; Young-Woo Kim; Keun Won Ryu; Jun Ho Lee; Byung-Ho Nam; Young-Iee Park Journal: Gut Liver Date: 2010-12-17 Impact factor: 4.519
Authors: Jan Kulig; Tadeusz Popiela; Piotr Kolodziejczyk; Marek Sierzega; Joanna Jedrys; Antoni M Szczepanik Journal: Langenbecks Arch Surg Date: 2007-07-06 Impact factor: 3.445
Authors: Joo Hyun Lim; Dong Ho Lee; Cheol Min Shin; Nayoung Kim; Young Soo Park; Hyun Chae Jung; In Sung Song Journal: J Korean Med Sci Date: 2014-11-21 Impact factor: 2.153