| Literature DB >> 15721946 |
Tomoharu Sano1, Hiroo Takagi, Louise F Morrison, James S Metcalf, Geoffrey A Codd, Kunimitsu Kaya.
Abstract
Two leucine aminopeptidase M inhibitors, cyanostatin A and B, were isolated from cyanobacterial water blooms at Loch Rescobie in Scotland, and specifically from a Microcystis species. Both inhibitors were lipopeptides containing 3-amino-2-hydroxydecanoic acid and weak inhibitors of protein phosphatase (PP2A). Both strongly inhibited the activity of leucine aminopeptidase M with IC50 values of 40 and 12 ng/ml, respectively.Entities:
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Year: 2005 PMID： 15721946 DOI： 10.1016/j.phytochem.2005.01.001
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072