| Literature DB >> 15721758 |
Pinelopi Lundquist1, Helena Wilking, A Urban Höglund, Johan Sandell, Mats Bergström, Per Hartvig, Bengt Långström.
Abstract
The serotonin transporter radioligand [11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, or [11C]DASB, was examined in order to assess its potential for measuring fluctuations in endogenous serotonin concentrations with positron emission tomography. Binding characteristics of [11C]DASB and the propensity for serotonin to displace the tracer were explored in rat brain homogenates. Experiments showed that serotonin displaced [11C]DASB in vitro. Ex vivo experiments performed after tranylcypromine injection (3 or 15 mg/kg) showed a dose-dependent trend in radioactivity uptake and suggested that serotonin may compete with [11C]DASB for transporter binding.Entities:
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Year: 2005 PMID： 15721758 DOI： 10.1016/j.nucmedbio.2004.12.001
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408